AustralieFrV1, Main, Exploration, bibRecord, 007035

PHF6 mutations in T-cell acute lymphoblastic leukemia

Identifieur interne : 007035 ( Main/Exploration ); précédent : 007034; suivant : 007036

PHF6 mutations in T-cell acute lymphoblastic leukemia

Auteurs : Pieter Van Vlierberghe [États-Unis, Belgique, Pays-Bas] ; Teresa Palomero [États-Unis] ; Hossein Khiabanian [États-Unis] ; Joni Van Der Meulen [Belgique] ; Mireia Castillo [États-Unis] ; Nadine Van Roy [Belgique] ; Barbara De Moerloose [Belgique] ; Jan Philippé [Belgique] ; Sara González-García [Espagne] ; María L. Toribio [Espagne] ; Tom Taghon [Belgique] ; Linda Zuurbier [Pays-Bas] ; Barbara Cauwelier [Belgique] ; Christine J. Harrison [Royaume-Uni] ; Claire Schwab [Royaume-Uni] ; Markus Pisecker [Autriche] ; Sabine Strehl [Autriche] ; Anton W. Langerak [Pays-Bas] ; Jozef Gecz [Australie] ; Edwin Sonneveld [Pays-Bas] ; Rob Pieters [Pays-Bas] ; Elisabeth Paietta [États-Unis] ; Jacob M. Rowe [Israël] ; Peter H. Wiernik [États-Unis] ; Yves Benoit [Belgique] ; Jean Soulier [France] ; Bruce Poppe [Belgique] ; Xiaopan Yao [États-Unis] ; Carlos Cordon-Cardo [États-Unis] ; Jules Meijerink [Pays-Bas] ; Raul Rabadan [États-Unis] ; Frank Speleman [Belgique] ; Adolfo Ferrando [États-Unis]

Source :

Nature genetics [ 1061-4036 ] ; 2010.

RBID : PMC:2847364

Abstract

Tumor suppressor genes on the X chromosome may skew the gender distribution of specific types of cancer1,2. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with an increased incidence in males3. In this study, we report the identification of inactivating mutations and deletions in the X-linked plant homeodomain finger 6 (PHF6) gene in 16% of pediatric and 38% of adult primary T-ALL samples. Notably, PHF6 mutations are almost exclusively found in T-ALL samples from male subjects. Mutational loss of PHF6 is significantly associated with leukemias driven by aberrant expression of the homeobox transcription factor oncogenes TLX1 and TLX3. Overall, these results identify PHF6 as a new X-linked tumor suppressor in T-ALL and point to a strong genetic interaction between PHF6 loss and aberrant expression of TLX transcription factors in the pathogenesis of this disease.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847364

DOI: 10.1038/ng.542
PubMed: 20228800
PubMed Central: 2847364

Affiliations:

Le document en format XML

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 mutations in T-cell acute lymphoblastic leukemia</title>
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<author><name sortKey="Gonzalez Garcia, Sara" sort="Gonzalez Garcia, Sara" uniqKey="Gonzalez Garcia S" first="Sara" last="González-García">Sara González-García</name>
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<author><name sortKey="Harrison, Christine J" sort="Harrison, Christine J" uniqKey="Harrison C" first="Christine J" last="Harrison">Christine J. Harrison</name>
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<author><name sortKey="Gecz, Jozef" sort="Gecz, Jozef" uniqKey="Gecz J" first="Jozef" last="Gecz">Jozef Gecz</name>
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<country xml:lang="fr">Australie</country>
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<affiliation wicri:level="1"><nlm:aff id="A14">Department of Pediatrics, University of Adelaide, Adelaide, Australia</nlm:aff>
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<wicri:regionArea>Department of Pediatrics, University of Adelaide, Adelaide</wicri:regionArea>
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<author><name sortKey="Sonneveld, Edwin" sort="Sonneveld, Edwin" uniqKey="Sonneveld E" first="Edwin" last="Sonneveld">Edwin Sonneveld</name>
<affiliation wicri:level="1"><nlm:aff id="A15">on behalf of the Dutch Childhood Oncology Group (DCOG), The Hague, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>on behalf of the Dutch Childhood Oncology Group (DCOG), The Hague</wicri:regionArea>
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<author><name sortKey="Pieters, Rob" sort="Pieters, Rob" uniqKey="Pieters R" first="Rob" last="Pieters">Rob Pieters</name>
<affiliation wicri:level="3"><nlm:aff id="A3">Department of Pediatric Oncology/Hematology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pediatric Oncology/Hematology, Erasmus MC, Rotterdam</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="A15">on behalf of the Dutch Childhood Oncology Group (DCOG), The Hague, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>on behalf of the Dutch Childhood Oncology Group (DCOG), The Hague</wicri:regionArea>
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<author><name sortKey="Paietta, Elisabeth" sort="Paietta, Elisabeth" uniqKey="Paietta E" first="Elisabeth" last="Paietta">Elisabeth Paietta</name>
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<placeName><region type="state">État de New York</region>
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</affiliation>
</author>
<author><name sortKey="Rowe, Jacob M" sort="Rowe, Jacob M" uniqKey="Rowe J" first="Jacob M" last="Rowe">Jacob M. Rowe</name>
<affiliation wicri:level="1"><nlm:aff id="A17">Rambam Medical Center and Technion, Israel Institute of Technology, Haifa, Israel</nlm:aff>
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</author>
<author><name sortKey="Wiernik, Peter H" sort="Wiernik, Peter H" uniqKey="Wiernik P" first="Peter H" last="Wiernik">Peter H. Wiernik</name>
<affiliation wicri:level="2"><nlm:aff id="A16">Montefiore Medical Center North, Bronx, New York, USA</nlm:aff>
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<author><name sortKey="Benoit, Yves" sort="Benoit, Yves" uniqKey="Benoit Y" first="Yves" last="Benoit">Yves Benoit</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Pediatric Hemato-Oncology, Ghent University Hospital, Ghent, Belgium</nlm:aff>
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</author>
<author><name sortKey="Soulier, Jean" sort="Soulier, Jean" uniqKey="Soulier J" first="Jean" last="Soulier">Jean Soulier</name>
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<author><name sortKey="Poppe, Bruce" sort="Poppe, Bruce" uniqKey="Poppe B" first="Bruce" last="Poppe">Bruce Poppe</name>
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<author><name sortKey="Yao, Xiaopan" sort="Yao, Xiaopan" uniqKey="Yao X" first="Xiaopan" last="Yao">Xiaopan Yao</name>
<affiliation wicri:level="2"><nlm:aff id="A19">Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea>
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</placeName>
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</author>
<author><name sortKey="Cordon Cardo, Carlos" sort="Cordon Cardo, Carlos" uniqKey="Cordon Cardo C" first="Carlos" last="Cordon-Cardo">Carlos Cordon-Cardo</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Pathology, Columbia University Medical Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Columbia University Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meijerink, Jules" sort="Meijerink, Jules" uniqKey="Meijerink J" first="Jules" last="Meijerink">Jules Meijerink</name>
<affiliation wicri:level="3"><nlm:aff id="A3">Department of Pediatric Oncology/Hematology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pediatric Oncology/Hematology, Erasmus MC, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
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<author><name sortKey="Rabadan, Raul" sort="Rabadan, Raul" uniqKey="Rabadan R" first="Raul" last="Rabadan">Raul Rabadan</name>
<affiliation wicri:level="4"><nlm:aff id="A5">Center for Computational Biology and Bioinformatics, Columbia University, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Computational Biology and Bioinformatics, Columbia University, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
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<orgName type="university">Université Columbia</orgName>
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<author><name sortKey="Speleman, Frank" sort="Speleman, Frank" uniqKey="Speleman F" first="Frank" last="Speleman">Frank Speleman</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea>
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<author><name sortKey="Ferrando, Adolfo" sort="Ferrando, Adolfo" uniqKey="Ferrando A" first="Adolfo" last="Ferrando">Adolfo Ferrando</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Institute for Cancer Genetics, Columbia University Medical Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Cancer Genetics, Columbia University Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
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<affiliation wicri:level="2"><nlm:aff id="A4">Department of Pathology, Columbia University Medical Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Columbia University Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
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<affiliation wicri:level="2"><nlm:aff id="A20">Department of Pediatrics, Columbia University Medical Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Columbia University Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
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<idno type="pmid">20228800</idno>
<idno type="pmc">2847364</idno>
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<idno type="doi">10.1038/ng.542</idno>
<date when="2010">2010</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>PHF6</italic>
 mutations in T-cell acute lymphoblastic leukemia</title>
<author><name sortKey="Van Vlierberghe, Pieter" sort="Van Vlierberghe, Pieter" uniqKey="Van Vlierberghe P" first="Pieter" last="Van Vlierberghe">Pieter Van Vlierberghe</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Institute for Cancer Genetics, Columbia University Medical Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Cancer Genetics, Columbia University Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea>
<wicri:noRegion>Ghent</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">Department of Pediatric Oncology/Hematology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pediatric Oncology/Hematology, Erasmus MC, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Palomero, Teresa" sort="Palomero, Teresa" uniqKey="Palomero T" first="Teresa" last="Palomero">Teresa Palomero</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Institute for Cancer Genetics, Columbia University Medical Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Cancer Genetics, Columbia University Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Pathology, Columbia University Medical Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Columbia University Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Khiabanian, Hossein" sort="Khiabanian, Hossein" uniqKey="Khiabanian H" first="Hossein" last="Khiabanian">Hossein Khiabanian</name>
<affiliation wicri:level="4"><nlm:aff id="A5">Center for Computational Biology and Bioinformatics, Columbia University, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Computational Biology and Bioinformatics, Columbia University, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Van Der Meulen, Joni" sort="Van Der Meulen, Joni" uniqKey="Van Der Meulen J" first="Joni" last="Van Der Meulen">Joni Van Der Meulen</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea>
<wicri:noRegion>Ghent</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Castillo, Mireia" sort="Castillo, Mireia" uniqKey="Castillo M" first="Mireia" last="Castillo">Mireia Castillo</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Pathology, Columbia University Medical Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Columbia University Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Roy, Nadine" sort="Van Roy, Nadine" uniqKey="Van Roy N" first="Nadine" last="Van Roy">Nadine Van Roy</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea>
<wicri:noRegion>Ghent</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Moerloose, Barbara" sort="De Moerloose, Barbara" uniqKey="De Moerloose B" first="Barbara" last="De Moerloose">Barbara De Moerloose</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Pediatric Hemato-Oncology, Ghent University Hospital, Ghent, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Pediatric Hemato-Oncology, Ghent University Hospital, Ghent</wicri:regionArea>
<wicri:noRegion>Ghent</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Philippe, Jan" sort="Philippe, Jan" uniqKey="Philippe J" first="Jan" last="Philippé">Jan Philippé</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Clinical Chemistry, Immunology and Microbiology, Ghent University Hospital, Ghent, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Clinical Chemistry, Immunology and Microbiology, Ghent University Hospital, Ghent</wicri:regionArea>
<wicri:noRegion>Ghent</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gonzalez Garcia, Sara" sort="Gonzalez Garcia, Sara" uniqKey="Gonzalez Garcia S" first="Sara" last="González-García">Sara González-García</name>
<affiliation wicri:level="4"><nlm:aff id="A8">Centro de Biología Molecular “Severo Ochoa”, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centro de Biología Molecular “Severo Ochoa”, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
<settlement type="city">Madrid</settlement>
</placeName>
<orgName type="university">Université autonome de Madrid</orgName>
</affiliation>
</author>
<author><name sortKey="Toribio, Maria L" sort="Toribio, Maria L" uniqKey="Toribio M" first="María L" last="Toribio">María L. Toribio</name>
<affiliation wicri:level="4"><nlm:aff id="A8">Centro de Biología Molecular “Severo Ochoa”, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centro de Biología Molecular “Severo Ochoa”, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
<settlement type="city">Madrid</settlement>
</placeName>
<orgName type="university">Université autonome de Madrid</orgName>
</affiliation>
</author>
<author><name sortKey="Taghon, Tom" sort="Taghon, Tom" uniqKey="Taghon T" first="Tom" last="Taghon">Tom Taghon</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Clinical Chemistry, Immunology and Microbiology, Ghent University Hospital, Ghent, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Clinical Chemistry, Immunology and Microbiology, Ghent University Hospital, Ghent</wicri:regionArea>
<wicri:noRegion>Ghent</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zuurbier, Linda" sort="Zuurbier, Linda" uniqKey="Zuurbier L" first="Linda" last="Zuurbier">Linda Zuurbier</name>
<affiliation wicri:level="3"><nlm:aff id="A3">Department of Pediatric Oncology/Hematology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pediatric Oncology/Hematology, Erasmus MC, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cauwelier, Barbara" sort="Cauwelier, Barbara" uniqKey="Cauwelier B" first="Barbara" last="Cauwelier">Barbara Cauwelier</name>
<affiliation wicri:level="1"><nlm:aff id="A9">Department of Hematology, Hospital St-Jan, Bruges, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Hematology, Hospital St-Jan, Bruges</wicri:regionArea>
<wicri:noRegion>Bruges</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Harrison, Christine J" sort="Harrison, Christine J" uniqKey="Harrison C" first="Christine J" last="Harrison">Christine J. Harrison</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle</wicri:regionArea>
<wicri:noRegion>Newcastle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schwab, Claire" sort="Schwab, Claire" uniqKey="Schwab C" first="Claire" last="Schwab">Claire Schwab</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle</wicri:regionArea>
<wicri:noRegion>Newcastle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pisecker, Markus" sort="Pisecker, Markus" uniqKey="Pisecker M" first="Markus" last="Pisecker">Markus Pisecker</name>
<affiliation wicri:level="3"><nlm:aff id="A11">Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Strehl, Sabine" sort="Strehl, Sabine" uniqKey="Strehl S" first="Sabine" last="Strehl">Sabine Strehl</name>
<affiliation wicri:level="3"><nlm:aff id="A11">Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Langerak, Anton W" sort="Langerak, Anton W" uniqKey="Langerak A" first="Anton W" last="Langerak">Anton W. Langerak</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Department of Immunology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Immunology, Erasmus MC, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gecz, Jozef" sort="Gecz, Jozef" uniqKey="Gecz J" first="Jozef" last="Gecz">Jozef Gecz</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Department of Genetics and Molecular Pathology, University of Adelaide, Adelaide, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Molecular Pathology, University of Adelaide, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A14">Department of Pediatrics, University of Adelaide, Adelaide, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Pediatrics, University of Adelaide, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sonneveld, Edwin" sort="Sonneveld, Edwin" uniqKey="Sonneveld E" first="Edwin" last="Sonneveld">Edwin Sonneveld</name>
<affiliation wicri:level="1"><nlm:aff id="A15">on behalf of the Dutch Childhood Oncology Group (DCOG), The Hague, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>on behalf of the Dutch Childhood Oncology Group (DCOG), The Hague</wicri:regionArea>
<wicri:noRegion>The Hague</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pieters, Rob" sort="Pieters, Rob" uniqKey="Pieters R" first="Rob" last="Pieters">Rob Pieters</name>
<affiliation wicri:level="3"><nlm:aff id="A3">Department of Pediatric Oncology/Hematology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pediatric Oncology/Hematology, Erasmus MC, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A15">on behalf of the Dutch Childhood Oncology Group (DCOG), The Hague, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>on behalf of the Dutch Childhood Oncology Group (DCOG), The Hague</wicri:regionArea>
<wicri:noRegion>The Hague</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Paietta, Elisabeth" sort="Paietta, Elisabeth" uniqKey="Paietta E" first="Elisabeth" last="Paietta">Elisabeth Paietta</name>
<affiliation wicri:level="2"><nlm:aff id="A16">Montefiore Medical Center North, Bronx, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Montefiore Medical Center North, Bronx, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rowe, Jacob M" sort="Rowe, Jacob M" uniqKey="Rowe J" first="Jacob M" last="Rowe">Jacob M. Rowe</name>
<affiliation wicri:level="1"><nlm:aff id="A17">Rambam Medical Center and Technion, Israel Institute of Technology, Haifa, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Rambam Medical Center and Technion, Israel Institute of Technology, Haifa</wicri:regionArea>
<wicri:noRegion>Haifa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wiernik, Peter H" sort="Wiernik, Peter H" uniqKey="Wiernik P" first="Peter H" last="Wiernik">Peter H. Wiernik</name>
<affiliation wicri:level="2"><nlm:aff id="A16">Montefiore Medical Center North, Bronx, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Montefiore Medical Center North, Bronx, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Benoit, Yves" sort="Benoit, Yves" uniqKey="Benoit Y" first="Yves" last="Benoit">Yves Benoit</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Pediatric Hemato-Oncology, Ghent University Hospital, Ghent, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Pediatric Hemato-Oncology, Ghent University Hospital, Ghent</wicri:regionArea>
<wicri:noRegion>Ghent</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Soulier, Jean" sort="Soulier, Jean" uniqKey="Soulier J" first="Jean" last="Soulier">Jean Soulier</name>
<affiliation wicri:level="3"><nlm:aff id="A18">Hematology Laboratory APHP, INSERM U944, Hôpital Saint Louis, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hematology Laboratory APHP, INSERM U944, Hôpital Saint Louis, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poppe, Bruce" sort="Poppe, Bruce" uniqKey="Poppe B" first="Bruce" last="Poppe">Bruce Poppe</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea>
<wicri:noRegion>Ghent</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yao, Xiaopan" sort="Yao, Xiaopan" uniqKey="Yao X" first="Xiaopan" last="Yao">Xiaopan Yao</name>
<affiliation wicri:level="2"><nlm:aff id="A19">Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cordon Cardo, Carlos" sort="Cordon Cardo, Carlos" uniqKey="Cordon Cardo C" first="Carlos" last="Cordon-Cardo">Carlos Cordon-Cardo</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Pathology, Columbia University Medical Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Columbia University Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meijerink, Jules" sort="Meijerink, Jules" uniqKey="Meijerink J" first="Jules" last="Meijerink">Jules Meijerink</name>
<affiliation wicri:level="3"><nlm:aff id="A3">Department of Pediatric Oncology/Hematology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pediatric Oncology/Hematology, Erasmus MC, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rabadan, Raul" sort="Rabadan, Raul" uniqKey="Rabadan R" first="Raul" last="Rabadan">Raul Rabadan</name>
<affiliation wicri:level="4"><nlm:aff id="A5">Center for Computational Biology and Bioinformatics, Columbia University, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Computational Biology and Bioinformatics, Columbia University, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Speleman, Frank" sort="Speleman, Frank" uniqKey="Speleman F" first="Frank" last="Speleman">Frank Speleman</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea>
<wicri:noRegion>Ghent</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ferrando, Adolfo" sort="Ferrando, Adolfo" uniqKey="Ferrando A" first="Adolfo" last="Ferrando">Adolfo Ferrando</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Institute for Cancer Genetics, Columbia University Medical Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Cancer Genetics, Columbia University Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Pathology, Columbia University Medical Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Columbia University Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A20">Department of Pediatrics, Columbia University Medical Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Columbia University Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature genetics</title>
<idno type="ISSN">1061-4036</idno>
<idno type="eISSN">1546-1718</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><p id="P1">Tumor suppressor genes on the X chromosome may skew the gender distribution of specific types of cancer<xref rid="R1" ref-type="bibr">1</xref>
,<xref rid="R2" ref-type="bibr">2</xref>
. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with an increased incidence in males<xref rid="R3" ref-type="bibr">3</xref>
. In this study, we report the identification of inactivating mutations and deletions in the X-linked plant homeodomain finger 6 (<italic>PHF6</italic>
) gene in 16% of pediatric and 38% of adult primary T-ALL samples. Notably, <italic>PHF6</italic>
 mutations are almost exclusively found in T-ALL samples from male subjects. Mutational loss of <italic>PHF6</italic>
 is significantly associated with leukemias driven by aberrant expression of the homeobox transcription factor oncogenes <italic>TLX1</italic>
 and <italic>TLX3</italic>
. Overall, these results identify <italic>PHF6</italic>
 as a new X-linked tumor suppressor in T-ALL and point to a strong genetic interaction between <italic>PHF6</italic>
 loss and aberrant expression of TLX transcription factors in the pathogenesis of this disease.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Carrel, L" uniqKey="Carrel L">L Carrel</name>
</author>
<author><name sortKey="Cottle, Aa" uniqKey="Cottle A">AA Cottle</name>
</author>
<author><name sortKey="Goglin, Kc" uniqKey="Goglin K">KC Goglin</name>
</author>
<author><name sortKey="Willard, Hf" uniqKey="Willard H">HF Willard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carrel, L" uniqKey="Carrel L">L Carrel</name>
</author>
<author><name sortKey="Willard, Hf" uniqKey="Willard H">HF Willard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goldberg, Jm" uniqKey="Goldberg J">JM Goldberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aifantis, I" uniqKey="Aifantis I">I Aifantis</name>
</author>
<author><name sortKey="Raetz, E" uniqKey="Raetz E">E Raetz</name>
</author>
<author><name sortKey="Buonamici, S" uniqKey="Buonamici S">S Buonamici</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pui, Ch" uniqKey="Pui C">CH Pui</name>
</author>
<author><name sortKey="Robison, Ll" uniqKey="Robison L">LL Robison</name>
</author>
<author><name sortKey="Look, At" uniqKey="Look A">AT Look</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gnirke, A" uniqKey="Gnirke A">A Gnirke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lower, Km" uniqKey="Lower K">KM Lower</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Borjeson, M" uniqKey="Borjeson M">M Borjeson</name>
</author>
<author><name sortKey="Forssman, H" uniqKey="Forssman H">H Forssman</name>
</author>
<author><name sortKey="Lehmann, O" uniqKey="Lehmann O">O Lehmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Turner, G" uniqKey="Turner G">G Turner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baker, La" uniqKey="Baker L">LA Baker</name>
</author>
<author><name sortKey="Allis, Cd" uniqKey="Allis C">CD Allis</name>
</author>
<author><name sortKey="Wang, Gg" uniqKey="Wang G">GG Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dephoure, N" uniqKey="Dephoure N">N Dephoure</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matsuoka, S" uniqKey="Matsuoka S">S Matsuoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lowndes, Nf" uniqKey="Lowndes N">NF Lowndes</name>
</author>
<author><name sortKey="Toh, Gw" uniqKey="Toh G">GW Toh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Payer, B" uniqKey="Payer B">B Payer</name>
</author>
<author><name sortKey="Lee, Jt" uniqKey="Lee J">JT Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carrel, L" uniqKey="Carrel L">L Carrel</name>
</author>
<author><name sortKey="Willard, Hf" uniqKey="Willard H">HF Willard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferrando, Aa" uniqKey="Ferrando A">AA Ferrando</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Soulier, J" uniqKey="Soulier J">J Soulier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Vlierberghe, P" uniqKey="Van Vlierberghe P">P Van Vlierberghe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Grotel, M" uniqKey="Van Grotel M">M van Grotel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marks, Di" uniqKey="Marks D">DI Marks</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rumble, Sm" uniqKey="Rumble S">SM Rumble</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khiabanian, H" uniqKey="Khiabanian H">H Khiabanian</name>
</author>
<author><name sortKey="Vanvlierberghe, P" uniqKey="Vanvlierberghe P">P VanVlierberghe</name>
</author>
<author><name sortKey="Palomero, T" uniqKey="Palomero T">T Palomero</name>
</author>
<author><name sortKey="Ferrando, Aa" uniqKey="Ferrando A">AA Ferrando</name>
</author>
<author><name sortKey="Rabadan, R" uniqKey="Rabadan R">R Rabadan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clappier, E" uniqKey="Clappier E">E Clappier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Erdogan, F" uniqKey="Erdogan F">F Erdogan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lahortiga, I" uniqKey="Lahortiga I">I Lahortiga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Voss, Ak" uniqKey="Voss A">AK Voss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gonzalez Garcia, S" uniqKey="Gonzalez Garcia S">S Gonzalez-Garcia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moffat, J" uniqKey="Moffat J">J Moffat</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Autriche</li>
<li>Belgique</li>
<li>Espagne</li>
<li>France</li>
<li>Israël</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Communauté de Madrid</li>
<li>Hollande-Méridionale</li>
<li>Massachusetts</li>
<li>Vienne (Autriche)</li>
<li>État de New York</li>
<li>Île-de-France</li>
</region>
<settlement><li>Madrid</li>
<li>New York</li>
<li>Paris</li>
<li>Rotterdam</li>
<li>Vienne (Autriche)</li>
</settlement>
<orgName><li>Université Columbia</li>
<li>Université autonome de Madrid</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="État de New York"><name sortKey="Van Vlierberghe, Pieter" sort="Van Vlierberghe, Pieter" uniqKey="Van Vlierberghe P" first="Pieter" last="Van Vlierberghe">Pieter Van Vlierberghe</name>
</region>
<name sortKey="Castillo, Mireia" sort="Castillo, Mireia" uniqKey="Castillo M" first="Mireia" last="Castillo">Mireia Castillo</name>
<name sortKey="Cordon Cardo, Carlos" sort="Cordon Cardo, Carlos" uniqKey="Cordon Cardo C" first="Carlos" last="Cordon-Cardo">Carlos Cordon-Cardo</name>
<name sortKey="Ferrando, Adolfo" sort="Ferrando, Adolfo" uniqKey="Ferrando A" first="Adolfo" last="Ferrando">Adolfo Ferrando</name>
<name sortKey="Ferrando, Adolfo" sort="Ferrando, Adolfo" uniqKey="Ferrando A" first="Adolfo" last="Ferrando">Adolfo Ferrando</name>
<name sortKey="Ferrando, Adolfo" sort="Ferrando, Adolfo" uniqKey="Ferrando A" first="Adolfo" last="Ferrando">Adolfo Ferrando</name>
<name sortKey="Khiabanian, Hossein" sort="Khiabanian, Hossein" uniqKey="Khiabanian H" first="Hossein" last="Khiabanian">Hossein Khiabanian</name>
<name sortKey="Paietta, Elisabeth" sort="Paietta, Elisabeth" uniqKey="Paietta E" first="Elisabeth" last="Paietta">Elisabeth Paietta</name>
<name sortKey="Palomero, Teresa" sort="Palomero, Teresa" uniqKey="Palomero T" first="Teresa" last="Palomero">Teresa Palomero</name>
<name sortKey="Palomero, Teresa" sort="Palomero, Teresa" uniqKey="Palomero T" first="Teresa" last="Palomero">Teresa Palomero</name>
<name sortKey="Rabadan, Raul" sort="Rabadan, Raul" uniqKey="Rabadan R" first="Raul" last="Rabadan">Raul Rabadan</name>
<name sortKey="Wiernik, Peter H" sort="Wiernik, Peter H" uniqKey="Wiernik P" first="Peter H" last="Wiernik">Peter H. Wiernik</name>
<name sortKey="Yao, Xiaopan" sort="Yao, Xiaopan" uniqKey="Yao X" first="Xiaopan" last="Yao">Xiaopan Yao</name>
</country>
<country name="Belgique"><noRegion><name sortKey="Van Vlierberghe, Pieter" sort="Van Vlierberghe, Pieter" uniqKey="Van Vlierberghe P" first="Pieter" last="Van Vlierberghe">Pieter Van Vlierberghe</name>
</noRegion>
<name sortKey="Benoit, Yves" sort="Benoit, Yves" uniqKey="Benoit Y" first="Yves" last="Benoit">Yves Benoit</name>
<name sortKey="Cauwelier, Barbara" sort="Cauwelier, Barbara" uniqKey="Cauwelier B" first="Barbara" last="Cauwelier">Barbara Cauwelier</name>
<name sortKey="De Moerloose, Barbara" sort="De Moerloose, Barbara" uniqKey="De Moerloose B" first="Barbara" last="De Moerloose">Barbara De Moerloose</name>
<name sortKey="Philippe, Jan" sort="Philippe, Jan" uniqKey="Philippe J" first="Jan" last="Philippé">Jan Philippé</name>
<name sortKey="Poppe, Bruce" sort="Poppe, Bruce" uniqKey="Poppe B" first="Bruce" last="Poppe">Bruce Poppe</name>
<name sortKey="Speleman, Frank" sort="Speleman, Frank" uniqKey="Speleman F" first="Frank" last="Speleman">Frank Speleman</name>
<name sortKey="Taghon, Tom" sort="Taghon, Tom" uniqKey="Taghon T" first="Tom" last="Taghon">Tom Taghon</name>
<name sortKey="Van Der Meulen, Joni" sort="Van Der Meulen, Joni" uniqKey="Van Der Meulen J" first="Joni" last="Van Der Meulen">Joni Van Der Meulen</name>
<name sortKey="Van Roy, Nadine" sort="Van Roy, Nadine" uniqKey="Van Roy N" first="Nadine" last="Van Roy">Nadine Van Roy</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Van Vlierberghe, Pieter" sort="Van Vlierberghe, Pieter" uniqKey="Van Vlierberghe P" first="Pieter" last="Van Vlierberghe">Pieter Van Vlierberghe</name>
</region>
<name sortKey="Langerak, Anton W" sort="Langerak, Anton W" uniqKey="Langerak A" first="Anton W" last="Langerak">Anton W. Langerak</name>
<name sortKey="Meijerink, Jules" sort="Meijerink, Jules" uniqKey="Meijerink J" first="Jules" last="Meijerink">Jules Meijerink</name>
<name sortKey="Pieters, Rob" sort="Pieters, Rob" uniqKey="Pieters R" first="Rob" last="Pieters">Rob Pieters</name>
<name sortKey="Pieters, Rob" sort="Pieters, Rob" uniqKey="Pieters R" first="Rob" last="Pieters">Rob Pieters</name>
<name sortKey="Sonneveld, Edwin" sort="Sonneveld, Edwin" uniqKey="Sonneveld E" first="Edwin" last="Sonneveld">Edwin Sonneveld</name>
<name sortKey="Zuurbier, Linda" sort="Zuurbier, Linda" uniqKey="Zuurbier L" first="Linda" last="Zuurbier">Linda Zuurbier</name>
</country>
<country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Gonzalez Garcia, Sara" sort="Gonzalez Garcia, Sara" uniqKey="Gonzalez Garcia S" first="Sara" last="González-García">Sara González-García</name>
</region>
<name sortKey="Toribio, Maria L" sort="Toribio, Maria L" uniqKey="Toribio M" first="María L" last="Toribio">María L. Toribio</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Harrison, Christine J" sort="Harrison, Christine J" uniqKey="Harrison C" first="Christine J" last="Harrison">Christine J. Harrison</name>
</noRegion>
<name sortKey="Schwab, Claire" sort="Schwab, Claire" uniqKey="Schwab C" first="Claire" last="Schwab">Claire Schwab</name>
</country>
<country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Pisecker, Markus" sort="Pisecker, Markus" uniqKey="Pisecker M" first="Markus" last="Pisecker">Markus Pisecker</name>
</region>
<name sortKey="Strehl, Sabine" sort="Strehl, Sabine" uniqKey="Strehl S" first="Sabine" last="Strehl">Sabine Strehl</name>
</country>
<country name="Australie"><noRegion><name sortKey="Gecz, Jozef" sort="Gecz, Jozef" uniqKey="Gecz J" first="Jozef" last="Gecz">Jozef Gecz</name>
</noRegion>
<name sortKey="Gecz, Jozef" sort="Gecz, Jozef" uniqKey="Gecz J" first="Jozef" last="Gecz">Jozef Gecz</name>
</country>
<country name="Israël"><noRegion><name sortKey="Rowe, Jacob M" sort="Rowe, Jacob M" uniqKey="Rowe J" first="Jacob M" last="Rowe">Jacob M. Rowe</name>
</noRegion>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Soulier, Jean" sort="Soulier, Jean" uniqKey="Soulier J" first="Jean" last="Soulier">Jean Soulier</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

PHF6 mutations in T-cell acute lymphoblastic leukemia

PHF6 mutations in T-cell acute lymphoblastic leukemia

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	Serveur d'exploration sur les relations entre la France et l'Australie
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